标题： Facile preparation of magnetic metal organic frameworks core-shell nanoparticles for stimuli-responsive drug carrier
作者： Li, S (Li, Sheng); Bi, K (Bi, Ke); Xiao, L (Xiao, Ling); Shi, XW (Shi, Xiaowen)
来源出版物：NANOTECHNOLOGY 卷：28 期：49 文献编号：495601 DOI：10.1088/1361-6528/aa91c4 出版年：DEC 8 2017
摘要：Facile synthesis of core-shell magnetic MOFs for drug delivery is of significance due to the advantages of high drug load and easy separation. In this work, magnetic metal organic frameworks (MOFs, Fe3O4-NH2@MIL101-NH2) core-shell nanoparticles were synthesized rapidly in water phase by microwave irradiation using Fe3+ and 2-amino-1,4-benzenedicarboxylate (BDC-NH2) as metal ions and ligands respectively. The resulting magnetic MOFs exhibit large surface areas (96.04m(2) g(-1)), excellent magnetic response (20.47 emu g(-1)) and large mesopore volume (22.07 cm(3) g(-1)) along with spherical morphologies with the diameters ranging from 140-330 nm. Using doxorubicin (DOX) as a model drug, the drug loading capacity of Fe3O4-NH2@MIL101-NH2 could reach 36.02%, substantially higher than pristine MIL101-NH2. Importantly, the release of DOX could be controlled by pH as well as the meso pore size of MOFs. The cytotoxicity assay showed that the magnetic MOFs have low cytotoxicity and good biocompatibility. The results suggest great potential of the magnetic MOFs core-shell nanoparticles fabricated in this study on controlled drug release of DOX.
作者关键词：magnetic MOFs; microwave; facile synthesis; adsorption; drug release
扩展关键词： IRON-OXIDE NANOPARTICLES; HYDROGEN-PRODUCTION; PORE-SIZE; DELIVERY; NANOCOMPOSITES; COMPOSITES; ADSORPTION
通讯作者地址： Xiao, L; Shi, XW (reprint author), Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Sch Resource & Environm Sci, Wuhan 430072, Hubei, Peoples R China.
Xiao, L; Shi, XW (reprint author), Luojia Mt Wuchang, Wuhan 430072, Hubei, Peoples R China.
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[Li, Sheng; Bi, Ke; Xiao, Ling; Shi, Xiaowen] Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Sch Resource & Environm Sci, Wuhan 430072, Hubei, Peoples R China.
[Li, Sheng; Bi, Ke; Xiao, Ling; Shi, Xiaowen] Luojia Mt Wuchang, Wuhan 430072, Hubei, Peoples R China.
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