首页  >  科学研究  >  科研成果  >  正文
科研成果
博士生刘西京的论文在RSC ADVANCES 刊出
发布时间:2018-02-22 16:10:42     发布者:yz     浏览次数:

标题: Design of bright near-infrared-emitting quantum dots capped with different stabilizing ligands for tumor targeting

作者: Liu, XJ (Liu, Xijing); Zhou, PJ (Zhou, Peijiang); Liu, HY (Liu, Hongyu); Zhan, HJ (Zhan, Hongju); Zhang, Q (Zhang, Qiang); Zhao, YN (Zhao, Yanan); Chen, Y (Chen, Yun)

来源出版物:RSC ADVANCES 卷:8期:8 页码:4221-4229 DOI:10.1039/c7ra10824a 出版年: 2018

摘要: In this study, a facile formulation of near-infrared (NIR)-emitting CdHgTe/CdS/CdZnS quantum dots (QDs) was fabricated and coated with three different thiol ligands, N-acetyl-L-cysteine (NAC), 3-mercaptopropionic acid (MPA) and thioglycolic acid (TGA). The optical properties, morphology, hydrodynamic diameters, structure and surface chemistries of the developed QDs were comprehensively assessed. As a therapeutic drug, NAC provides excellent biocompatibility and anti-oxidant activity both in vitro and in vivo. Given their core-shell-shell structure, the QDs induced no toxicity in living bodies even at a concentration of 20 mg kg(-1). Compared with NAC-capped QDs, TGA- and MPA-capped QDs demonstrated poor tumor-targeting capabilities because of their larger hydrodynamic diameters and inferior biocompatibility. Furthermore, the use of different stabilizing ligands resulted in various major changes in organ biodistribution and clearance from the body. In terms of rapid metabolization through renal clearance, the NAC-capped core-shell-shell QDs will be an alternative probe in cellular metabolism studies and image-guided surgery for tumor targeting and removal.

入藏号: WOS:000423406900037

文献类型:Article

语种:English

扩展关键词: MICROWAVE SYNTHESIS; OPTICAL-PROPERTIES; CDTE NANOCRYSTALS; CADMIUM IONS; HIGH-QUALITY; NANOPARTICLES; CANCER; CELLS; PHOTOLUMINESCENCE; CYTOTOXICITY

通讯作者地址:Zhou, PJ (通讯作者),Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Sch Resource & Environm Sci, Wuhan 430079, Hubei, Peoples R China.

Chen, Y (通讯作者),Wuhan Univ, Sch Basic Med Sci, Dept Biomed Engn, Wuhan 430071, Hubei, Peoples R China.

电子邮件地址:zhoupj@whu.edu.cn; yunchen@whu.edu.cn

地址:

[Liu, Xijing; Zhou, Peijiang; Liu, Hongyu] Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Sch Resource & Environm Sci, Wuhan 430079, Hubei, Peoples R China.

[Zhan, Hongju] Jingchu Univ Technol, Jingmen 448000, Peoples R China.

[Zhang, Qiang; Zhao, Yanan; Chen, Yun] Wuhan Univ, Sch Basic Med Sci, Dept Biomed Engn, Wuhan 430071, Hubei, Peoples R China.

影响因子:3.108

信息服务
学院网站教师登录 学院办公电话 学校信息门户登录

版权所有 © 武汉大学资源与环境科学学院
地址:湖北省武汉市珞喻路129号 邮编:430079 
电话:027-68778381,68778284,68778296 传真:027-68778893