标题：Nanofibrous mats coated by homocharged biopolymer-layered silicate nanoparticles and their antitumor activity作者：Xin, Shangjing;Li, Xueyong; Zhu, Ya; Zhang, Ting; Lei, Zhanjun; Li,Wei; Zhou, Xue; Deng, Hongbing
来源出版物：COLLOIDS AND SURFACES B-BIOINTERFACES 卷：105 页：137-143 DOI：10.1016/j.colsurfb.2012.12.010出版年：MAY 1 2013
摘要：Quaternized chitosan (QC)-organic rectorite (OREC) intercalated composites based nanoparticles were immobilized on cellulose acetate nanofibrous mats by layer-by-layer deposition technique via hydrogen bonds. The key design of those mats was the utilization of all negatively charged materials to reduce the quantity of nanoparticles immobilized on the fibers and then the cytotoxicity of the mats. The intercalated structure in nanoparticles was confirmed by selected area electron diffraction. The morphology and composition of NPs-assembled nanofibrous mats were studied by field emission scanning electron microscopy and X-ray photoelectron spectroscopy. The results trended to give clues as how the assembly process varied by adding OREC. MTT assay and cell culture experiments showed that NPs-assembled nanofibrous mats were commendably compatible with normal cells and could selectively kill human lung carcinoma epithelial cells. Hemolysis test indicated these mats had excellent blood compatibility. As a result, QC-OREC NPs-assembled nanofibrous mats by homocharged deposition process can be considered as a novel alternative method for cancer therapy.
作者关键词：Quaternized chitosan, Organic rectorite, Nanoparticles, Layer-by-layer assembly, Biocompatibility, Antitumor activity
扩展关键词：QUATERNIZED CHITOSAN; DRUG-DELIVERY; COMPOSITES; NANOCOMPOSITES; CYTOTOXICITY; CELLS; FILMS; BEHAVIOR; CANCER; TUMOR
通讯作者地址：Zhou, Xue ;Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan 430030, Peoples R China.
[Xin, Shangjing; Deng, Hongbing] WuhanUniv, Sch Resource & Environm Sci, Dept Environm Sci,Wuhan430079, Peoples RChina.
[Xin, Shangjing; Zhu, Ya; Zhang, Ting; Deng, Hongbing] Huazhong Agr Univ, Coll Food Sci & Technol,Wuhan430070, Peoples RChina.
[Li, Xueyong; Lei, Zhanjun] Fourth Mil Med Univ, Tangdu Hosp, Dept Plast Surg, Xian 710038, Peoples R China.
[Li, Wei]HubeiEngn Univ, Coll Chem & Mat Sci, Xiaogan 432000, Peoples RChina.
[Zhou, Xue] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan 430030, Peoples R China.
[Zhou, Xue] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth,Wuhan430030, Peoples RChina.
研究方向：Biophysics; Chemistry; Materials Science
版权所有 © 武汉大学资源与环境科学学院