标题： Enhanced physical and biological properties of silk fibroin nanofibers by layer-by-layer deposition of chitosan and rectorite
作者： Chen, JJ (Chen, Jiajia); Cheng, G (Cheng, Gu); Liu, R (Liu, Rong); Zheng, Y (Zheng, Yue); Huang, MT (Huang, Mengtian); Yi, Y (Yi, Yang); Shi, XW (Shi, Xiaowen); Du, YM (Du, Yumin); Deng, HB (Deng, Hongbing)
来源出版物：JOURNAL OF COLLOID AND INTERFACE SCIENCE卷：523页码: 208-216 DOI：10.1016/j.jcis.2018.03.093 出版年： AUG 1 2018
摘要：The search for biodegradable and biocompatible materials applied to the antibacterial field has become a significant topic of interest worldwide. In this study, the electrospinning and electrostatic layer-by-layer self-assembly (LBL) techniques were applied to achieve composite mats with enhanced physical and biological properties. Electrospun silk fibroin (SF) was selected as the substrate, and chitosan (CS) and rectonte (REC) were assembled on the surface of the substrate as positively and negatively charged layers via electrostatic LBL. The morphology, composition and structure of the mats were examined, and the results suggested that LBL modification was successful. In addition, the variation of the bilayer numbers and the component of the outmost layer could affect the morphology and the physical and biological properties of LBL mats. Additionally, the morphology and the water contact angle investigation results of the as-prepared mats indicated that the surface features were changed through the LBL process, resulting in a rougher surface than in pure SF mats. Moreover, the mechanical properties of the SF mats were improved after the LBL process. Furthermore, the antibacterial activity of the LBL self-assembled SF mats against E. coll and S aureus with a concentration of 10(6) CFU/mL were 84 and 92%, respectively. The cellculture experiments demonstrated that the mats maintained superior biocompatibihty after the introduction of CS and REC.
作者关键词：Silk fibroin; Chitosan; Rectorite; Layer-by-layer; Antibacterial properties; Biocompatibility
扩展关键词： ENDOTHELIAL-CELL ADHESIVENESS; ANTIBACTERIAL ACTIVITY; GOLD NANOPARTICLES; BONE REGENERATION; EDIBLE FILMS; SILVER; MATS; MEMBRANES; SURFACES; COATINGS
通讯作者地址：Deng, HB (reprint author), Wuhan Univ, Sch Resource & Environm Sci, Hubei Key Lab Biomass Resource Chem & Environm Bi, Hubei Int Sci & Technol Cooperat Base Sustainable, Wuhan 430079, Hubei, Peoples R China.
[Chen, Jiajia; Liu, Rong; Huang, Mengtian; Yi, Yang; Shi, Xiaowen; Du, Yumin; Deng, Hongbing] Wuhan Univ, Sch Resource & Environm Sci, Hubei Key Lab Biomass Resource Chem & Environm Bi, Hubei Int Sci & Technol Cooperat Base Sustainable, Wuhan 430079, Hubei, Peoples R China.
[Cheng, Gu; Zheng, Yue] Wuhan Univ, Sch & Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol Hu, Wuhan 430079, Hubei, Peoples R China.
[Cheng, Gu; Zheng, Yue] Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan 430079, Hubei, Peoples R China.
[Huang, Mengtian] Guangxi Univ, Sch Chem & Chem Engn, Guangxi Key Lab Petrochem Resource Proc & Proc In, Nanning 530004, Peoples R China.
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